Aran F Labrijn: search on Z-Library

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1

Bispecific antibodies: a mechanistic review of the pipeline

Labrijn, Aran F., Janmaat, Maarten L., Reichert, Janice M., Parren, Paul W. H. I.

Journal:

Nature Reviews Drug Discovery

Year:

2019

Language:

english

File:

PDF, 1.68 MB

english, 2019

2

When binding is enough: nonactivating antibody formats

Aran F Labrijn, Rob C Aalberse, Janine Schuurman

Journal:

Current Opinion in Immunology

Year:

2008

Language:

english

File:

PDF, 990 KB

english, 2008

3

Improved Breadth and Potency of an HIV-1-Neutralizing Human Single-chain Antibody by Random Mutagenesis and Sequential Antigen Panning

Mei-Yun Zhang, Yuuei Shu, Donna Rudolph, Ponraj Prabakaran, Aran F. Labrijn, Michael B. Zwick, Renu B. Lal, Dimiter S. Dimitrov

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 820 KB

english, 2004

4

Impact of IgG oligomerization state on the potency of complement-dependent cytotoxicity

Beurskens, Frank J., de Jong, Rob N., Wang, Guanbo, Voorhorst, Marleen, van den Bremer, Ewald T.J., Labrijn, Aran F., Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.

Journal:

Year:

2016

Language:

english

File:

PDF, 68 KB

english, 2016

5

Reply to Fab-arm exchange

Labrijn, Aran F, Schuurman, Janine, van de Winkel, Jan G J, Parren, Paul W H I

Journal:

Nature Biotechnology

Year:

2010

Language:

english

File:

PDF, 188 KB

english, 2010

6

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

Labrijn, Aran F., Meesters, Joyce I., Bunce, Matthew, Armstrong, Anthony A., Somani, Sandeep, Nesspor, Tom C., Chiu, Mark L., Altintaş, Işil, Verploegen, Sandra, Schuurman, Janine, Parren, Paul W. H.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.25 MB

english, 2017

7

Opening the door to innovation

Schuurman, Janine, Graus, Yvo F, Labrijn, Aran F, Ruuls, Sigrid R, Parren, Paul WHI

Journal:

Year:

2014

Language:

english

File:

PDF, 707 KB

english, 2014

8

Controlled Fab-arm exchange for the generation of stable bispecific IgG1

Labrijn, Aran F, Meesters, Joyce I, Priem, Patrick, de Jong, Rob N, van den Bremer, Ewald T J, van Kampen, Muriel D, Gerritsen, Arnout F, Schuurman, Janine, Parren, Paul W H I

Journal:

Nature Protocols

Year:

2014

Language:

english

File:

PDF, 921 KB

english, 2014

9

Fab-arm exchange

Schuurman, Janine, Labrijn, Aran F., Parren, Paul W.H.I.

Journal:

Year:

2012

Language:

english

File:

PDF, 328 KB

english, 2012

10

Kinetic Mechanism of Controlled Fab-Arm Exchange for the Formation of Bispecific Immunoglobulin G1 Antibodies

Goulet, Dennis R, Orcutt, Steven J., Zwolak, Adam, Rispens, Theo, Labrijn, Aran, de Jong, Rob N., Atkins, William M., Chiu, Mark L

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

11

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Labrijn, Aran F, Buijsse, Antonio Ortiz, van den Bremer, Ewald T J, Verwilligen, Annemiek Y W, Bleeker, Wim K, Thorpe, Susan J, Killestein, Joep, Polman, Chris H, Aalberse, Rob C, Schuurman, Janine

Journal:

Nature Biotechnology

Year:

2009

Language:

english

File:

PDF, 503 KB

english, 2009

12

Fc–Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer

Theo Rispens, Joyce Meesters, Tamara H. den Bleker, Pleuni Ooijevaar-De Heer, Janine Schuurman, Paul W.H.I. Parren, Aran Labrijn, Rob C. Aalberse

Journal:

Molecular Immunology

Year:

2013

Language:

english

File:

PDF, 918 KB

english, 2013

13

Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope †,‡

Darbha, Ramalakshmi, Phogat, Sanjay, Labrijn, Aran F., Shu, Yuuei, Gu, Yijun, Andrykovitch, Michelle, Zhang, Mei-Yun, Pantophlet, Ralph, Martin, Loic, Vita, Claudio, Burton, Dennis R., Dimitrov, Dimit

Journal:

Year:

2004

Language:

english

File:

PDF, 690 KB

english, 2004

14

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, M

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.97 MB

english, 2017

15

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

Rebecca J. Rose, Aran F. Labrijn, Ewald T.J. van den Bremer, Stefan Loverix, Ignace Lasters, Patrick H.C. van Berkel, Jan G.J. van de Winkel, Janine Schuurman, Paul W.H.I. Parren, Albert J.R. Heck

Journal:

Year:

2011

Language:

english

File:

PDF, 721 KB

english, 2011

16

Cysteine-SILAC mass spectrometry enables the identification and quantitation of scrambled inter-chain disulfide bonds: preservation of native heavy-light chain pairing in bispecific IgGs generated by controlled Fab-arm exchange.

van den Bremer, Ewald T.J., Labrijn, Aran F., van den Boogaard, Ramon, Priem, Patrick, Scheffler, Kai, Melis, Joost P.M., Schuurman, Janine, Parren, Paul, de Jong, Rob N

Journal:

Analytical Chemistry

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

17

CD3-bispecific antibody therapy turns solid tumors into inflammatory sites but does not install protective memory

Benonisson, Hreinn, Altıntaş, Işıl, Sluijter, Marjolein, Verploegen, Sandra, Labrijn, Aran, Schuurhuis, Danita H, Houtkamp, Mischa A., Verbeek, J. Sjef, Schuurman, Janine, van Hall, Thorbald

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 1.41 MB

english, 2018

18

Novel strategy for the selection of human recombinant Fab fragments to membrane proteins from a phage-display library

Aran F Labrijn, Marco H.G.M Koppelman, Janneke Verhagen, Mieke C Brouwer, Hanneke Schuitemaker, C.Erik Hack, Han G Huisman

Journal:

Journal of Immunological Methods

Year:

2002

Language:

english

File:

PDF, 358 KB

english, 2002

19

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

Rose, Rebecca J., van Berkel, Patrick H.C., van den Bremer, Ewald T.J., Labrijn, Aran F., Vink, Tom, Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

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